Case Studies & Scientific Research
The evidence supporting personalised nutrition and fitness is powerful.
Research shows that you are twice as likely to make nutrition changes if they are based on your DNA and personalised to you. Weight loss results are up to twice as good as those based on traditional calorie-restricted dieting, and fitness training synced with your genes results in 3x better increases in performance measures.
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European Journal of Human Genetics, May 2014, "Taking gene-based diet in real life: a prospective study."
Increased knowledge in the field of nutrigenetics led to the development of different genetic risk scores and dietary interventions. We have decided to test the efficacy of a gene-based diet (gdiet from www.genex.me) on 191 obese (BMI>25) attending the same nutritional center. Participants were randomly divided in two groups (87 test and 104 controls). For both groups a standard nutritional plan was defined subtracting 600 calories from individual need. DNA from the test group was analyzed for 19 genes known to impact on different metabolic areas and taste. Diet was modulated according to individual genetic profile (i.e. people with a non-favorable lipid metabolism profile were given less lipids in their diet) without varying the overall amount of calories. Physical activities plans were personalized in the same way in the two groups. No significant differences in age, sex and BMI distribution were present in the two groups. Follow-up took place every six months for 2y and showed, in both groups, BMI loss over time and similar compliance. Very interestingly, people in the test group (gene-based diet) lost 33% more weight than controls corresponding to 0.47 BMI points for the square root of time (-1.36 in the control group vs -1.83 in the test group, p=1.8x10-8). Similarly, the percentage of lean mass increased more in the test group (+6.2%) than controls (+5.3%) (p=2x10-4). In conclusion, present findings indicate that a gene-based diet might be more effective in helping people loosing weight as compared to standard nutritional plans.
Weight Loss & DNA Personalisation
Athletes & Genetic Fitness
Personalised Diets & Nutrigenomics
Overview of Nutrigenomics
Omega-3 & Nutrigenomcs
Cardiovascular Health & Nutrigenomics
Methylation & Nutrigenomics